Italian newspaper Tuttosport claimed on Thursday that Isco is planning to leave Real Madrid for another big European side.
Among those keen on the Spain international are Juventus and Manchester City, two teams with coaches who highly rate the player.
Isco's bench role in the La Liga -- and the fact he wasn't named in the squad against Roma this week -- have reactivated rumours about an exit.
His relationship with new Madrid coach Santiago Solari is not good and other clubs may look to push for his signing because of that.
Tuttosport also say that Juve are also chasing Marcelo. Last summer, when they signed Cristiano Ronaldo, they made a move for the Brazilian, a close friend of Ronaldo's.