Javier Mascherano was not able to finish Barcelona's game against Sevilla because of a minor hamstring strain that will keep him out for one week.
It means he will not feature at the weekend, with Samuel Umtiti likely to partner Gerard Pique against Real Betis as La Liga kicks off.
Jeremy Mathieu is injured - he hurt his own hamstring in the first leg. Meanwhile Andres Iniesta also suffered a knee injury against the Andalusians.
Umtiti played well against Sevilla on Wednesday night, although he conceded a penalty when Mariano Ferreira's shot struck his hand in Barcelona's box.