Gerard Pique, Sergio Busquets, Andres Iniesta and Ivan Rakitic will all miss Barcelona’s game against Celta Vigo on Thursday.
Rakitic is still recovering from surgery on a broken finger but the other three have been rested by Ernesto Valverde.
The Barça coach hinted earlier on Monday that he would make changes against Celta with Saturday’s Copa del Rey final in mind.
Lucas Digne returns to the squad after missing the last three weeks injured, while Aleix Vidal and Yerry Mina are recalled, too.
Lionel Messi and Luis Suarez are included, though, as Barcelona look to make it 40 games unbeaten in the league.
Valverde’s side need seven points from their remaining six La Liga games to wrap up a seventh title in 10 years.