Andres Iniesta has not been included in Barcelona's squad for the clash with Villarreal on Sunday afternoon.
The Blaugrana head to El Madrigal without their talisman and captain, who had been suffering some muscle problems, which forced Vicente del Bosque to leave him out of the Spain squad too.
Iniesta had missed training on Saturday so was always likely to be a doubt for the game.
Adriano returns after an injury lay-off, while Thomas Vermaelen, Douglas and Jordi Masip are left out.
Rafinha, who has been given medical clearance to play, was not included by Luis Enrique, who does not want to rush the star back to action after damaging his knee ligaments six months ago.