Bravo, Mathieu, Kroos and more.... who is making their Clasico debut?
As well as Luis Enrique, there are several players on both sides preparing to make Clasico debuts.
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BARCELONA
Luis Suarez - He could make his actual debut after his ban. He may start the game or be a luxury option for Luis Enrique on the bench
Ivan Rakitic - The midfielder from Sevilla has dazzled at the Camp Nou, fits perfectly into the coach's plans and could have a vital role on Saturday
Claudio Bravo - Yet to let in a single goal this season and will be praying that continues at the Bernabeu
Jeremy Mathieu - His arrival at Barcelona was widely criticised because he cost a lot, but has shut many mouths with his good performances.
Munir El Haddadi - The big surprise of the season so far, adds youthful energy to the attack
Sandro Ramirez - Another surprise, has supplied goals and looked strong beyond his years
Others: Ter Stegen, Rafinha, Jordi Masip, Douglas, Vermaelen
REAL MADRID
Toni Kroos - Amazing value at only €25million, he is leading the midfield for Madrid. True class and hard for Barca to contain
James Rodriguez - A Florentino Perez signing after shining at the World Cup, but has played well so far. High technical quality
Keylor Navas - Tough for the keeper to sit on the bench after an amazing season with Levante, but he knew what he was signing up for
Javier Hernandez - A last minute signing and is usually having to be content with a role off the bench